Authors:
Kleiner D, Ditrói K.
Abstract:
Cannabidiol, a cannabinoid and serotonin receptor antagonist, may
alleviate hyperphagia without the side effects of rimonabant (for
example depression and reduced insulin sensitivity). Similar to the
peroxisome proliferator-activated receptor-gamma agonists, it may also
help the differentation of adipocytes. Cannabidiol has an
immunomodulating effect, as well, that helps lessen the progression of
atherosclerosis induced by high glucose level. It may also be effective
in fighting ischaemic diseases, the most harmful complications of
metabolic syndrome. However, it can only be administered as an adjuvant
therapy because of its low binding potency, and its inhibiting effect of
cytochrome P450 enzymes should also be considered. Nevertheless, it may
be beneficially used in adjuvant therapy because of its few side
effects.